A Functional Polymorphism in THBS2 that Affects Alternative Splicing and MMP Binding Is Associated with Lumbar-Disc Herniation

Lumbar-disc herniation (LDH), one of the most common musculoskeletal diseases, has strong genetic determinants. Recently, several genes that encode extracellular matrix (ECM) proteins in the intervertebral disc have been reported to associate with LDH. Thrombospondins (THBSs) 1 and 2 are good candid...

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Detalhes bibliográficos
Main Authors: Hirose, Yuichiro, Chiba, Kazuhiro, Karasugi, Tatsuki, Nakajima, Masahiro, Kawaguchi, Yoshiharu, Mikami, Yasuo, Furuichi, Tatsuya, Mio, Futoshi, Miyake, Atsushi, Miyamoto, Takeshi, Ozaki, Kouichi, Takahashi, Atsushi, Mizuta, Hiroshi, Kubo, Toshikazu, Kimura, Tomoatsu, Tanaka, Toshihiro, Toyama, Yoshiaki, Ikegawa, Shiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Human Genetics 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427305/
https://ncbi.nlm.nih.gov/pubmed/18455130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2008.03.013
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