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Loss of VHL in RCC Reduces Repair and Alters Cellular Response to Benzo[a]pyrene
Mutations of the von Hippel-Lindau (VHL) tumor suppressor gene occur in the majority of sporadic renal-cell carcinomas (RCC). Loss of VHL function is associated with stabilization of hypoxia-inducible factor α (HIFα). We and others demonstrated that there is a two-way interaction between the aryl hy...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3809518/ https://ncbi.nlm.nih.gov/pubmed/24195061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00270 |
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