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SSR504734 enhances basal expression of prepulse inhibition but exacerbates the disruption of prepulse inhibition by apomorphine

RATIONALE: Inhibition of glycine transporter 1 (GlyT1) elevates extracellular glycine and can thus increase N-methyl-D-aspartate receptor (NMDAR) excitability in the brain. The potent GlyT1 inhibitor, SSR504734, has also been shown to potentiate the behavioural effects of direct and indirect dopamin...

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Библиографические подробности
Главные авторы: Singer, Philipp, Zhang, Weining, Yee, Benjamin K.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809335/
https://ncbi.nlm.nih.gov/pubmed/23736281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-013-3160-3
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