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Immune cell derived C3a and C5a costimulate human T cell alloimmunity

Emerging evidence indicates that complement provides costimulatory signals for murine T cells but whether complement impacts human T cells remains unclear. We observed production of complement activation products C3a and C5a during in vitro cultures of human T cells responding to allogeneic dendriti...

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Bibliographic Details
Main Authors: Cravedi, Paolo, Leventhal, Jeremy, Lakhani, Parth, Ward, Stephen C., Donovan, Michael J., Heeger, Peter S.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809075/
https://ncbi.nlm.nih.gov/pubmed/24033923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.12405
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