Structure of NADP(+)-dependent glutamate dehydrogenase from Escherichia coli: Reflections on the basis of coenzyme specificity in the family of glutamate dehydrogenases

Glutamate dehydrogenases (EC 1.4.1.2–4) catalyse the oxidative deamination of l-glutamate to α-ketoglutarate using NAD(+) and/or NADP(+) as a cofactor. Subunits of homo-hexameric bacterial enzymes comprise a substrate-binding Domain I followed by a nucleotide binding Domain II. The reaction occurs i...

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Bibliographic Details
Main Authors: Sharkey, Michael A., Oliveira, Tânia F., Engel, Paul C., Khan, Amir R.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809065/
https://ncbi.nlm.nih.gov/pubmed/23879525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12439
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