CD137 ligand reverse signaling skews hematopoiesis towards myelopoiesis during aging

CD137 is a costimulatory molecule expressed on activated T cells. Its ligand, CD137L, is expressed on the surface of hematopoietic progenitor cells, and upon binding to CD137 induces reverse signaling into hematopoietic progenitor cells promoting their activation, proliferation and myeloid different...

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Bibliografiska uppgifter
Huvudupphovsmän: Tang, Qianqiao, Koh, Liang Kai, Jiang, Dongsheng, Schwarz, Herbert
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2013
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808697/
https://ncbi.nlm.nih.gov/pubmed/23945137
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