Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology

The aryl hydrocarbon receptor (AhR) is a nuclear receptor that regulates xenobiotic metabolism and detoxification. Herein, we report a previously undescribed role for the AhR signaling pathway as an essential defense mechanism in the pathogenesis of early dry age-related macular degeneration (AMD),...

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Autors principals: Hu, Peng, Herrmann, Rolf, Bednar, Amanda, Saloupis, Peter, Dwyer, Mary A., Yang, Ping, Qi, Xiaoping, Thomas, Russell S., Jaffe, Glenn J., Boulton, Michael E., McDonnell, Donald P., Malek, Goldis
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808645/
https://ncbi.nlm.nih.gov/pubmed/24106308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307574110
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