Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription

Menin is a scaffold protein encoded by the multiple endocrine neoplasia type 1 (MEN1) gene in humans, and it interacts with a variety of transcriptional proteins to control active or repressive cellular processes. Here, we show that heterozygous ablation of Men1 in female mice reduces chemical carci...

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Bibliographische Detailangaben
Hauptverfasser: Xu, Bin, Li, Shan-Hua, Zheng, Rong, Gao, Shu-Bin, Ding, Li-Hong, Yin, Zhen-Yu, Lin, Xiao, Feng, Zi-Jie, Zhang, Sheng, Wang, Xiao-Min, Jin, Guang-Hui
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808599/
https://ncbi.nlm.nih.gov/pubmed/24101467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312022110
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