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Contribution of Helicobacter hepaticus Cytolethal Distending Toxin Subunits to Human Epithelial Cell Cycle Arrest and Apoptotic Death in vitro

BACKGROUND: Cytolethal distending toxin (CDT) is the only known virulence factor found in H. hepaticus, the cause of chronic typhlocolitis and hepatitis leading to colonic and hepatocellular carcinomas in mice. Interaction of the tripartite polypeptide CdtA, CdtB and CdtC subunits produced by H. hep...

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Detalhes bibliográficos
Main Authors: Liyanage, Namal P.M., Dassanayake, Rohana P., Kuszynski, Charles A., Duhamel, Gerald E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808484/
https://ncbi.nlm.nih.gov/pubmed/23895367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/hel.12084
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