Eukaryotic Initiation Factor 2α - a Downstream Effector of Mammalian Target of Rapamycin - Modulates DNA Repair and Cancer Response to Treatment

In an effort to circumvent resistance to rapamycin – an mTOR inhibitor - we searched for novel rapamycin-downstream-targets that may be key players in the response of cancer cells to therapy. We found that rapamycin, at nM concentrations, increased phosphorylation of eukaryotic initiation factor (eI...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tuval-Kochen, Liron, Paglin, Shoshana, Keshet, Gilmor, Lerenthal, Yaniv, Nakar, Charles, Golani, Tamar, Toren, Amos, Yahalom, Joachim, Pfeffer, Raphael, Lawrence, Yaacov
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2013
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808413/
https://ncbi.nlm.nih.gov/pubmed/24204783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077260
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