Central Precocious Puberty Caused by Mutations in the Imprinted Gene MKRN3

BACKGROUND: The onset of puberty is first detected as an increase in pulsatile secretion of gonadotropin-releasing hormone (GnRH). Early activation of the hypothalamic–pituitary–gonadal axis results in central precocious puberty. The timing of pubertal development is driven in part by genetic factor...

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Main Authors: Abreu, Ana Paula, Dauber, Andrew, Macedo, Delanie B., Noel, Sekoni D., Brito, Vinicius N., Gill, John C., Cukier, Priscilla, Thompson, Iain R., Navarro, Victor M., Gagliardi, Priscila C., Rodrigues, Tânia, Kochi, Cristiane, Longui, Carlos Alberto, Beckers, Dominique, de Zegher, Francis, Montenegro, Luciana R., Mendonca, Berenice B., Carroll, Rona S., Hirschhorn, Joel N., Latronico, Ana Claudia, Kaiser, Ursula B.
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808195/
https://ncbi.nlm.nih.gov/pubmed/23738509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1302160
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