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Central Precocious Puberty Caused by Mutations in the Imprinted Gene MKRN3
BACKGROUND: The onset of puberty is first detected as an increase in pulsatile secretion of gonadotropin-releasing hormone (GnRH). Early activation of the hypothalamic–pituitary–gonadal axis results in central precocious puberty. The timing of pubertal development is driven in part by genetic factor...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3808195/ https://ncbi.nlm.nih.gov/pubmed/23738509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1302160 |
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