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The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress
Several proto-oncogenes and tumor suppressors regulate the production of ribosomes. Ribosome biogenesis is a major consumer of cellular energy, and defects result in p53 activation via repression of mouse double minute 2 (MDM2) homolog by the ribosomal proteins RPL5 and RPL11. Here, we report that R...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cell Press
2013
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3808153/ https://ncbi.nlm.nih.gov/pubmed/24120868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.08.049 |
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