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Biology and therapeutic potential of PI3K signaling in ER+/HER2-negative breast cancer
PI3K is a central node mediating growth factor receptor signaling. With its downstream effectors such as AKT and mTOR, and its crosstalk with the RAS/RAF/MEK/MAPK pathway, it plays a vital role in cancer cell proliferation, metabolism, and survival. Recent breast cancer (BC) molecular portraits deli...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3808116/ https://ncbi.nlm.nih.gov/pubmed/24011769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.breast.2013.08.001 |
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