Upregulation of Mucin4 in ER-positive/HER2-Overexpressing Breast Cancer Xenografts with Acquired Resistance to Endocrine and HER2-Targeted Therapies

BACKGROUND: We studied resistance to endocrine and HER2-targeted therapies using a xenograft model of estrogen receptor positive (ER)/HER2-overexpressing breast cancer. Here, we report a novel phenotype of drug resistance in this model. METHODS: MCF7/HER2-18 xenografts were treated with endocrine th...

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Bibliographic Details
Main Authors: Chen, Albert C., Migliaccio, Ilenia, Rimawi, Mothaffar, Lopez-Tarruella, Sara, Creighton, Chad J., Massarweh, Suleiman, Huang, Catherine, Wang, Yen-Chao, Batra, Surinder K., Gutierrez, M. Carolina, Osborne, C. Kent, Schiff, Rachel
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408244/
https://ncbi.nlm.nih.gov/pubmed/22644656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-012-2082-9
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