Absence of a p53 allele delays nitrogen mustard-induced early apoptosis and inflammation of murine skin

Bifunctional alkylating agent sulfur mustard (SM) and its analog nitrogen mustard (NM) cause DNA damage leading to cell death, and potentially activating inflammation. Transcription factor p53 plays a critical role in DNA damage by regulating cell cycle progression and apoptosis. Earlier studies by...

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Hlavní autoři: Inturi, Swetha, Tewari-Singh, Neera, Jain, Anil K., Roy, Srirupa, White, Carl W., Agarwal, Rajesh
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808076/
https://ncbi.nlm.nih.gov/pubmed/23845566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2013.06.013
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