A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung.

Effective gene therapy for lung tissue requires the use of efficient vehicles to deliver the gene of interest into lung cells. When plasmid DNA encoding chloramphenicol acetyltransferase (CAT) was administered intranasally to BALB/c mice without carrier lipids, CAT activity was detected in mouse lun...

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Detalhes bibliográficos
Main Authors: Wheeler, C J, Felgner, P L, Tsai, Y J, Marshall, J, Sukhu, L, Doh, S G, Hartikka, J, Nietupski, J, Manthorpe, M, Nichols, M, Plewe, M, Liang, X, Norman, J, Smith, A, Cheng, S H
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC38078/
https://ncbi.nlm.nih.gov/pubmed/8876156
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