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A Specific Population of Abnormal Prion Protein Aggregates Is Preferentially Taken Up by Cells and Disaggregated in a Strain-Dependent Manner

Prion diseases are characterized by the conversion of the soluble protease-sensitive host-encoded prion protein (PrP(C)) into its aggregated, protease-resistant, and infectious isoform (PrP(Sc)). One of the earliest events occurring in cells following exposure to an exogenous source of prions is the...

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Detalhes bibliográficos
Main Authors: Choi, Young Pyo, Priola, Suzette A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807341/
https://ncbi.nlm.nih.gov/pubmed/23966386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01484-13
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