Cytomegalovirus Vaccine Strain Towne-Derived Dense Bodies Induce Broad Cellular Immune Responses and Neutralizing Antibodies That Prevent Infection of Fibroblasts and Epithelial Cells

Human cytomegalovirus (HCMV), a betaherpesvirus, can cause severe disease in immunosuppressed patients and following congenital infection. A vaccine that induces both humoral and cellular immunity may be required to prevent congenital infection. Dense bodies (DBs) are complex, noninfectious particle...

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Autores principales: Cayatte, Corinne, Schneider-Ohrum, Kirsten, Wang, Zhaoti, Irrinki, Alivelu, Nguyen, Nga, Lu, Janine, Nelson, Christine, Servat, Esteban, Gemmell, Lorraine, Citkowicz, Andrzej, Liu, Yi, Hayes, Gregory, Woo, Jennifer, Van Nest, Gary, Jin, Hong, Duke, Gregory, McCormick, A. Louise
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807294/
https://ncbi.nlm.nih.gov/pubmed/23926341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01554-13
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