The PA and HA Gene-Mediated High Viral Load and Intense Innate Immune Response in the Brain Contribute to the High Pathogenicity of H5N1 Avian Influenza Virus in Mallard Ducks

Most highly pathogenic avian influenza A viruses cause only mild clinical signs in ducks, serving as an important natural reservoir of influenza A viruses. However, we isolated two H5N1 viruses that are genetically similar but differ greatly in virulence in ducks. A/Chicken/Jiangsu/k0402/2010 (CK10)...

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Bibliografiske detaljer
Main Authors: Hu, Jiao, Hu, Zenglei, Mo, Yiqun, Wu, Qiwen, Cui, Zhu, Duan, Zhiqiang, Huang, Junqing, Chen, Hongzhi, Chen, Yuxin, Gu, Min, Wang, Xiaoquan, Hu, Shunlin, Liu, Huimou, Liu, Wenbo, Liu, Xiaowen, Liu, Xiufan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807287/
https://ncbi.nlm.nih.gov/pubmed/23926340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00760-13
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