Design, Synthesis and Characterization of Novel Small Molecular Inhibitors of Ephrin-B2 Binding to EphB4

EphB4 is a member of the large Eph receptor tyrosine kinase family. By interacting with its preferred ligand ephrin-B2, which is also a transmembrane protein, EphB4 plays a role in a variety of physiological and pathological processes ranging from bone remodeling to cancer malignancy. EphB4-ephrin-B...

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Detalhes bibliográficos
Main Authors: Duggineni, Srinivas, Mitra, Sayantan, Noberini, Roberta, Han, Xiaofeng, Lin, Nan, Xu, Yan, Tian, Wang, An, Jing, Pasquale, Elena B., Huang, Ziwei
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807243/
https://ncbi.nlm.nih.gov/pubmed/23253822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.12.005
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