Epidermal Growth Factor Receptor Kinase Domain Mutations in Esophageal and Pancreatic Adenocarcinomas

PURPOSE: Specific activating mutations within the epidermal growth factor receptor (EGFR) identify a subset of non – small cell lung cancers with dramatic sensitivity to the specific tyrosine kinase inhibitors (TKI), gefitinib and erlotinib. Despite the abundant expression of EGFR protein in a broad...

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Hauptverfasser: Kwak, Eunice L., Jankowski, Janusz, Thayer, Sarah P., Lauwers, Gregory Y., Brannigan, Brian W., Harris, Patricia L., Okimoto, Ross A., Haserlat, Sara M., Dris coll, David R., Ferry, David, Muir, Beth, Settleman, Jeff, Fuchs, Charles S., Kulke, Matthew H., Ryan, David P., Clark, Jeff W., Sgroi, Dennis C., Haber, Daniel A., Bell, Daphne W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807136/
https://ncbi.nlm.nih.gov/pubmed/16857803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-06-0189
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