Oncogenic Activity of Epidermal Growth Factor Receptor Kinase Mutant Alleles Is Enhanced by the T790M Drug Resistance Mutation

Activating mutations in the epidermal growth factor receptor (EGFR) characterize a subset of non–small cell lung cancers (NSCLC) with extraordinary sensitivity to targeted tyrosine kinase inhibitors (TKI). A single secondary EGFR mutation, T790M, arising in cis with the primary activating mutation,...

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Hauptverfasser: Godin-Heymann, Nadia, Bryant, Ianthe, Rivera, Miguel N., Ulkus, Lindsey, Bell, Daphne W., Riese, David J., Settleman, Jeffrey, Haber, Daniel A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882853/
https://ncbi.nlm.nih.gov/pubmed/17671201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-06-4625
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