Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38α MAPK During Insulin Resistance

Cardiac failure is a major cause of death in patients with type 2 diabetes, but the molecular mechanism that links diabetes to heart failure remains unclear. Insulin resistance is a hallmark of type 2 diabetes, and insulin receptor substrates 1 and 2 (IRS1 and IRS2) are the major insulin-signaling c...

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Detalhes bibliográficos
Main Authors: Qi, Yajuan, Xu, Zihui, Zhu, Qinglei, Thomas, Candice, Kumar, Rajesh, Feng, Hao, Dostal, David E., White, Morris F., Baker, Kenneth M., Guo, Shaodong
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806607/
https://ncbi.nlm.nih.gov/pubmed/24159000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0095
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