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Discovery and Evaluation of Thiazinoquinones as Anti-Protozoal Agents
Pure compound screening has identified the dioxothiazino-quinoline-quinone ascidian metabolite ascidiathiazone A (2) to be a moderate growth inhibitor of Trypanosoma brucei rhodesiense (IC(50) 3.1 μM) and Plasmodium falciparum (K1 dual drug resistant strain) (IC(50) 3.3 μM) while exhibiting low leve...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3806465/ https://ncbi.nlm.nih.gov/pubmed/24022732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md11093472 |
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