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Abr, a negative regulator of Rac, attenuates cockroach allergen-induced asthma in a mouse model
Abr deactivates Rac, a master molecular switch that positively regulates many immune cell functions, by converting it to its GDP-bound conformation. Here we report that in the absence of Abr function, cockroach allergen (CRA)-immunized mice experienced a fatal asthma attack when challenged with CRA....
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3806305/ https://ncbi.nlm.nih.gov/pubmed/24058174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202603 |
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