DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8(+) T cells independently of PD-1 and PD-L1

CD8(+) T cells specific for islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) have been implicated in type 1 diabetes in both humans and non-obese diabetic (NOD) mice, in which T cells specific for IGRP(206–214) are highly prevalent. We sought to manipulate these pathogen...

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Detalhes bibliográficos
Main Authors: Mukherjee, Gayatri, Geliebter, Ari, Babad, Jeffrey, Santamaria, Pere, Serreze, David V., Freeman, Gordon J., Tarbell, Kristin V., Sharpe, Arlene, DiLorenzo, Teresa P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806169/
https://ncbi.nlm.nih.gov/pubmed/24021877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxt031
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