Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

Recognition of injured mitochondria for degradation by macroautophagy is essential for cellular health, but the mechanisms remain poorly understood. Cardiolipin is an inner mitochondrial membrane phospholipid. We found that rotenone, staurosporine, 6-hydroxydopamine and other pro-mitophagy stimuli c...

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Auteurs principaux: Chu, Charleen T., Ji, Jing, Dagda, Ruben K., Jiang, Jian Fei, Tyurina, Yulia Y., Kapralov, Alexandr A., Tyurin, Vladimir A., Yanamala, Naveena, Shrivastava, Indira H., Mohammadyani, Dariush, Wang, Kent Zhi Qiang, Zhu, Jianhui, Klein-Seetharaman, Judith, Balasubramanian, Krishnakumar, Amoscato, Andrew A., Borisenko, Grigory, Huang, Zhentai, Gusdon, Aaron M., Cheikhi, Amin, Steer, Erin K., Wang, Ruth, Baty, Catherine, Watkins, Simon, Bahar, Ivet, Bayir, Hülya, Kagan, Valerian E.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806088/
https://ncbi.nlm.nih.gov/pubmed/24036476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2837
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