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Histones-Mediated Lymphocyte Apoptosis during Sepsis Is Dependent on p38 Phosphorylation and Mitochondrial Permeability Transition

Lymphocyte apoptosis is one reason for immunoparalysis seen in sepsis, although the triggers are unknown. We hypothesized that molecules in plasma, which are up-regulated during sepsis, may be responsible for this. In this study, peripheral lymphocyte apoptosis caused by extracellular histones was c...

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Detalhes bibliográficos
Main Authors: Liu, Zhan-Guo, Ni, Shu-Yuan, Chen, Gui-Ming, Cai, Jing, Guo, Zhen-Hui, Chang, Ping, Li, Yu-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805602/
https://ncbi.nlm.nih.gov/pubmed/24167561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077131
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