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Differential effects of zidovudine and zidovudine triphosphate on mitochondrial permeability transition and oxidative phosphorylation

1. The effects of zidovudine (ZDV) and zidovudine triphosphate (ZDV-3P) on Ca(2+)-induced mitochondrial permeability transition (MPT), respiratory control ratio (RCR) and ATP synthesis have been investigated on isolated rat liver mitochondria. 2. ZDV slightly but significantly decreased RCR and ATP...

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Main Authors: Elimadi, Aziz, Morin, Didier, Albengres, Edith, Chauvet-Monges, Anne-Marie, Allain, Valérie, Crevat, Aimé, Tillement, Jean-Paul
格式: Artigo
語言:Inglês
出版: 1997
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564835/
https://ncbi.nlm.nih.gov/pubmed/9257906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701276
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