Lynch Syndrome-Associated Extracolonic Tumors Are Rare in Two Extended Families With the Same EPCAM Deletion

OBJECTIVES: The Lynch syndrome (LS) is an inherited cancer syndrome showing a preponderance of colorectal cancer (CRC) in context with endometrial cancer and several other extracolonic cancers, which is due to pathogenic mutations in the mismatch repair (MMR) genes, MLH1, MSH2, MSH6, and PMS2. Some...

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Hlavní autoři: Lynch, Henry T., Riegert-Johnson, Douglas L., Snyder, Carrie, Lynch, Jane F., Hagenkord, Jill, Boland, C. Richard, Rhees, Jennifer, Thibodeau, Stephen N., Boardman, Lisa A., Davies, Janine, Kuiper, Roland P., Hoogerbrugge, Nicoline, Ligtenberg, Marjolijn J.L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805505/
https://ncbi.nlm.nih.gov/pubmed/21769135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ajg.2011.203
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