Mutation of the Protein Kinase I Alpha Leucine Zipper Domain Produces Hypertension and Progressive Left Ventricular Hypertrophy: A Novel Mouse Model of Age-Dependent Hypertensive Heart Disease

Hypertensive heart disease causes significant mortality in older patients, yet there is an incomplete understanding of molecular mechanisms that regulate age-dependent hypertensive left ventricular hypertrophy (LVH). Therefore, we tested the hypothesis that the cGMP-dependent protein kinase G I alph...

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Detalhes bibliográficos
Main Authors: Blanton, Robert M., Takimoto, Eiki, Aronovitz, Mark, Thoonen, Robrecht, Kass, David A., Karas, Richard H., Mendelsohn, Michael E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805294/
https://ncbi.nlm.nih.gov/pubmed/23657971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glt042
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