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Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells
Blood cell production relies on the coordinated activities of hematopoietic stem cells (HSCs) and multipotent and lineage-restricted progenitors. Here, we identify Notchless (Nle) as a critical factor for HSC maintenance under both homeostatic and cytopenic conditions. Nle deficiency leads to a rapi...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3804936/ https://ncbi.nlm.nih.gov/pubmed/24062412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122019 |
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