Endothelin-1 receptor antagonists regulate cell surface-associated protein disulfide isomerase in sickle cell disease

Increased endothelin-1 (ET-1) levels, disordered thiol protein status, and erythrocyte hydration status play important roles in sickle cell disease (SCD) through unresolved mechanisms. Protein disulfide isomerase (PDI) is an oxidoreductase that mediates thiol/disulfide interchange reactions. We prov...

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Autores principales: Prado, Gregory N., Romero, Jose R., Rivera, Alicia
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2013
Materias:
Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804753/
https://ncbi.nlm.nih.gov/pubmed/23913858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-228577
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