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Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress
A “longevity ” gene, sirtuin 1 (SIRT1), can attenuate age-dependent induction of left ventricular dysfunction. This study aimed to characterize the role of SIRT1 in the tolerance of aged heart to ischemic insults. Male C57BL/6 young (4–6 mo) and aged (24–26 mo) mice were used to determine the role o...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Federation of American Societies for Experimental Biology
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3804750/ https://ncbi.nlm.nih.gov/pubmed/23024374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-216473 |
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