Impaired Macrophage Migration Inhibitory Factor (MIF)-AMPK Activation and Ischemic Recovery in the Senescent Heart

BACKGROUND: Elderly patients are more sensitive to myocardial ischemia, which results in higher mortality. We investigated how aging impacts the cardioprotective AMP-activated protein kinase (AMPK) signaling pathway. METHODS AND RESULTS: Ischemic AMPK activation was impaired in aged compared to youn...

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Detalhes bibliográficos
Main Authors: Ma, Heng, Wang, Jingying, Thomas, D Paul, Tong, Chao, Leng, Lin, Wang, Wenkui, Merk, Melanie, Zierow, Swen, Bernhagen, Jürgen, Ren, Jun, Bucala, Richard, Li, Ji
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907453/
https://ncbi.nlm.nih.gov/pubmed/20606117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.953208
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