Serum VEGF-D concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial

BACKGROUND: VEGF-D is a lymphangiogenic growth factor that has a key role in tumour metastasis. Serum VEGF-D concentrations are increased in most patients with lymphangioleiomyomatosis, a rare neoplasm associated with mTOR-activating tuberous sclerosis gene mutations, lymphadenopathy, metastatic spr...

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Main Authors: Young, Lisa R, Lee, Hye-Seung, Inoue, Yoshikazu, Moss, Joel, Singer, Lianne G, Strange, Charlie, Nakata, Koh, Barker, Alan F, Chapman, Jeffrey T, Brantly, Mark L, Stocks, James M, Brown, Kevin K, Lynch, Joseph P, Goldberg, Hilary J, Downey, Gregory P, Swigris, Jeffrey J, Taveira-DaSilva, Angelo M, Krischer, Jeffrey P, Trapnell, Bruce C, McCormack, Francis X
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804556/
https://ncbi.nlm.nih.gov/pubmed/24159565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S2213-2600(13)70090-0
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