Acute modulation of endothelial Akt/PKB activity alters nitric oxide–dependent vasomotor activity in vivo

The serine/threonine protein kinase Akt (protein kinase B) phosphorylates endothelial cell nitric oxide synthase (eNOS) and enhances its ability to generate nitric oxide (NO). Because NO is an important regulator of vasomotor tone, we investigated whether Akt can regulate endothelium-dependent vasom...

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Huvudupphovsmän: Luo, Zhengyu, Fujio, Yasushi, Kureishi, Yasuko, Rudic, Radu Daniel, Daumerie, Geraldine, Fulton, David, Sessa, William C., Walsh, Kenneth
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2000
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC380252/
https://ncbi.nlm.nih.gov/pubmed/10953024
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