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The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals

Recent studies suggest that statins can function to protect the vasculature in a manner that is independent of their lipid-lowering activity. We show here that statins rapidly activate the protein kinase Akt/PKB in endothelial cells. Accordingly, simvastatin enhanced phosphorylation of the endogenou...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kureishi, Yasuko, Luo, Zhengyu, Shiojima, Ichiro, Bialik, Ann, Fulton, David, Lefer, David J., Sessa, William C., Walsh, Kenneth
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2000
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828689/
https://ncbi.nlm.nih.gov/pubmed/10973320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/79510
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