The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals

Recent studies suggest that statins can function to protect the vasculature in a manner that is independent of their lipid-lowering activity. We show here that statins rapidly activate the protein kinase Akt/PKB in endothelial cells. Accordingly, simvastatin enhanced phosphorylation of the endogenou...

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Autores principales: Kureishi, Yasuko, Luo, Zhengyu, Shiojima, Ichiro, Bialik, Ann, Fulton, David, Lefer, David J., Sessa, William C., Walsh, Kenneth
Formato: Artigo
Lenguaje:Inglês
Publicado: 2000
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828689/
https://ncbi.nlm.nih.gov/pubmed/10973320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/79510
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