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A selective inhibitor of the osteoclastic V-H(+)-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats

A potent and selective inhibitor of the osteoclastic V-H(+)-ATPase, (2Z,4E)-5-(5,6-dichloro-2-indolyl)-2-methoxy-N-(1,2,2,6,6-pentamethylpiperidin-4-yl) -2,4-pentadienamide (SB 242784), was evaluated in two animal models of bone resorption. SB 242784 completely prevented retinoid-induced hypercalcem...

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Autori principali: Visentin, Luciano, Dodds, Robert A., Valente, Maurizio, Misiano, Paola, Bradbeer, Jeremy N., Oneta, Sergio, Liang, Xiaoguang, Gowen, Maxine, Farina, Carlo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC380241/
https://ncbi.nlm.nih.gov/pubmed/10903347
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