Divergent contributions of conserved active site residues to transcription by eukaryotic RNA polymerases I and II

Multisubunit RNA polymerases (msRNAPs) exhibit high sequence and structural homology, especially within their active sites, which is generally thought to result in msRNAP functional conservation. However, we show that mutations in the trigger loop (TL) in the largest subunit of RNA polymerase I (Pol...

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Hlavní autoři: Viktorovskaya, Olga V., Engel, Krysta L., French, Sarah L., Cui, Ping, Vandeventer, Paul J., Pavlovic, Emily M., Beyer, Ann L., Kaplan, Craig D., Schneider, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801175/
https://ncbi.nlm.nih.gov/pubmed/23994471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.07.044
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