CRL4A-FBXW5–mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth

DLC1 encodes a RhoA GTPase-activating protein and tumor suppressor lost in cancer by genomic deletion or epigenetic silencing and loss of DLC1 gene transcription. We unexpectedly identified non-small cell lung cancer (NSCLC) cell lines and tumor tissue that expressed DLC1 mRNA yet lacked DLC1 protei...

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Detalhes bibliográficos
Main Authors: Kim, Tai Young, Jackson, Sarah, Xiong, Yue, Whitsett, Timothy G., Lobello, Janine R., Weiss, Glen J., Tran, Nhan Le, Bang, Yung-Jue, Der, Channing J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801067/
https://ncbi.nlm.nih.gov/pubmed/24082123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1306358110
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