DLC-1 Suppresses Non-Small Cell Lung Cancer Growth and Invasion By RhoGAP-Dependent and Independent Mechanisms

Expression of the tumor suppressor deleted in liver cancer-1 (DLC-1) is lost in non-small cell lung (NSCLC) and other human carcinomas, and ectopic DLC-1 expression dramatically reduces proliferation and tumorigenicity. DLC-1 is a multidomain protein that includes a Rho GTPase Activating Protein (Rh...

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Main Authors: Healy, Kevin D., Hodgson, Louis, Kim, Tai-Young, Shutes, Adam, Maddileti, Savitri, Juliano, Rudolph L., Hahn, Klaus M., Harden, T. Kendall, Bang, Yung-Jue, Der, Channing J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679972/
https://ncbi.nlm.nih.gov/pubmed/17932950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20389
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