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Molecular crowding limits translation and cell growth
Bacterial growth is crucially dependent on protein synthesis and thus on the cellular abundance of ribosomes and related proteins. Here, we show that the slow diffusion of the bulky tRNA complexes in the crowded cytoplasm imposes a physical limit on the speed of translation, which ultimately limits...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3801028/ https://ncbi.nlm.nih.gov/pubmed/24082144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310377110 |
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