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Probing the protein-folding mechanism using denaturant and temperature effects on rate constants

Protein folding has been extensively studied, but many questions remain regarding the mechanism. Characterizing early unstable intermediates and the high–free-energy transition state (TS) will help answer some of these. Here, we use effects of denaturants (urea, guanidinium chloride) and temperature...

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主要な著者: Guinn, Emily J., Kontur, Wayne S., Tsodikov, Oleg V., Shkel, Irina, Record, M. Thomas
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801023/
https://ncbi.nlm.nih.gov/pubmed/24043778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311948110
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