Dysregulated NOD2 predisposes SAMP1/YitFc mice to chronic intestinal inflammation

Nucleotide-binding oligomerization domain-containing 2 (NOD2) is an intracellular receptor that plays an essential role in innate immunity as a sensor of a component of the bacterial cell wall, muramyl dipeptide (MDP). Crohn’s disease (CD)-associated NOD2 variants lead to defective innate immune res...

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Main Authors: Corridoni, Daniele, Kodani, Tomohiro, Rodriguez-Palacios, Alexander, Pizarro, Theresa T., Xin, Wei, Nickerson, Kourtney P., McDonald, Christine, Ley, Klaus F., Abbott, Derek W., Cominelli, Fabio
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801018/
https://ncbi.nlm.nih.gov/pubmed/24082103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311657110
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