Chemical cross-linking of HIV-1 Env for direct TLR7/8 ligand conjugation compromises recognition of conserved antigenic determinants

Covalent conjugation of immune-stimulatory compounds to protein antigens is a potential means to self-adjuvant non-replicating subunit vaccines. Previously, it was demonstrated that covalent coupling of a Toll-like receptor (TLR) ligand to the exterior HIV-1 envelope glycoprotein, gp120, enhanced it...

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Detaylı Bibliyografya
Asıl Yazarlar: Feng, Yu, Forsell, Mattias N. E., Flynn, Barbara, Adams, William, Loré, Karin, Seder, Robert, Wyatt, Richard T., Karlsson Hedestam, Gunilla B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800776/
https://ncbi.nlm.nih.gov/pubmed/24074567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.07.028
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