Synthesis and Characterization of Pt(IV) Fluorescein Conjugates to Investigate Pt(IV) Intracellular Transformations

Pt(IV) anticancer compounds typically operate as prodrugs that are reduced in the hypoxic environment of cancer cells, losing two axial ligands in the process to generate active Pt(II) species. Here we report the synthesis of two fluorescent Pt(IV) prodrugs of cisplatin in order to image and evaluat...

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Detaylı Bibliyografya
Asıl Yazarlar: Song, Ying, Suntharalingam, Kogularamanan, Yeung, Jessica S., Royzen, Maksim, Lippard, Stephen J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800427/
https://ncbi.nlm.nih.gov/pubmed/23957697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc400281a
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