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Targeting Sonic Hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-Like Kinases

Medulloblastoma (MB) is the most common malignant brain tumor in children. While aggressive surgery, radiation, and chemotherapy have improved outcomes, survivors suffer severe long-term side effects, and many patients still succumb to their disease. For patients whose tumors are driven by mutations...

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Main Authors: Markant, Shirley L., Esparza, Lourdes Adriana, Sun, Jesse, Barton, Kelly L., McCoig, Lisa M., Grant, Gerald A., Crawford, John R., Levy, Michael L., Northcott, Paul A., Shih, David, Remke, Marc, Taylor, Michael D., Wechsler-Reya, Robert J.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800039/
https://ncbi.nlm.nih.gov/pubmed/24067506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4258
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