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Inhibition of cdk9 during Herpes Simplex Virus 1 Infection Impedes Viral Transcription

During herpes simplex virus 1 (HSV-1) infection there is a loss of the serine-2 phosphorylated form of RNA polymerase II (RNAP II) found in elongation complexes. This occurs in part because RNAP II undergoes ubiquitination and proteasomal degradation during times of highly active viral transcription...

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Autori principali: Ou, Mark, Sandri-Goldin, Rozanne M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799718/
https://ncbi.nlm.nih.gov/pubmed/24205359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079007
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